Meaning

• (extremely vulgar, dismissal) To go to hell, to disappear, go away or to screw oneself.

  "I wish you'd just fuck off."

• To annoy, irritate.

  "It really fucks me off when you do that."

• To fritter; to fuck around.

• To die or leave unexpectedly.

  "He fucked off."

Meaning

• Go away! Get lost!

• Expression of disagreement or disbelief.

  "Fuck off! You are joking, aren't you?"