Meaning

• To tighten or secure with screws.

• To raise (rent, fees, etc.) to extortionate levels.

• To raise or summon up.

  "trying to screw up enough courage to ask her out"

• To twist into a contorted state.

  "The baby screwed up his face and began to bawl."

• To squint.

• To make a mess of; to ruin.

• To blunder; to make a mistake.