Meaning

• Physical matter; material.

• The essential part of anything; the most vital part.

• Substantiality; solidity; firmness.

  "Some textile fabrics have little substance."

• Material possessions; estate; property; resources.

  "a man of substance"

• A form of matter that has constant chemical composition and characteristic properties.

• Drugs (illegal narcotics)

  "substance abuse"

• Hypostasis.

Meaning

• To give substance to; to make real or substantial.