Meaning

• A sharp pinch or jerk; a twist or twitch.

  "a tweak of the nose"

• A slight adjustment or modification.

  "He is running so many tweaks it is hard to remember how it looked originally."

• Trouble; distress; tweag.

• A prostitute.

• An additional input to a block cipher, used in conjunction with the key to select the permutation computed by the cipher.

Meaning

• To pinch and pull with a sudden jerk and twist; to twitch.

  "to tweak the nose."

• To adjust slightly; to fine-tune.

  "If we tweak the colors towards blue, it will look more natural."

• To twit or tease.

• To abuse methamphetamines, especially crystal meth.

• To exhibit symptoms of methamphetamine abuse, such as extreme nervousness, compulsiveness, erratic motion, excitability; possibly a blend of twitch and freak.

• To exhibit extreme nervousness, evasiveness when confronted by law enforcement or other authority (e.g., customs agents, border patrol, teacher, etc.), mimicking methamphetamine abuse symptoms.